2022 Fiscal Year Annual Research Report
Elucidating the role of CD72-C1q interactions in Systemic Lupus Erythematosus
| Project/Area Number |
22K15487
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
スルタン ソフィア・シェリル 東京医科歯科大学, 難治疾患研究所, 非常勤講師 (20838437)
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| Project Period (FY) |
2022-04-01 – 2023-03-31
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| Keywords | CD72 / C1Q / SLE |
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| Outline of Annual Research Achievements |
Systemic Lupus Erythematosus is an autoimmune disease in which B cells play an integral role through autoantibody secretion. Our lab has previously provided evidence of the involvement of CD72, an inhibitory B cell receptor in SLE development. In this project, we investigated the possibility that CD72 is a receptor for C1q ( a complement protein that binds to apoptotic cells ). Invitro studies showed an interaction between CD72 and C1q. For further investigation, functional analysis was done to study if a fusion protein composed of CD72 and C1q can inhibit B cell responses to apoptotic cells. To extend the scope of the study to an in vivo level, a targeting vector expressing a fusion protein composed of the globular domain of C1q fused to the CD72 receptor was created.
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