Elucidation of the immunosenescence mechanism by analysis of novel age-associated B cell subsets

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15497
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kyushu University
• Principal Investigator: Hatano Shinya 九州大学, 生体防御医学研究所, 助教 (90834929)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: B細胞 / 加齢性B細胞 / 自己免疫疾患 / 液性免疫老化

Outline of Final Research Achievements

I has identified a new age-assosiated B cell marker candidate gene X (referred to as X as it has not been published) that is highly expressed in aging mouse B cells, and attempted to analyze the function of X in B cells. young mouse spleen B cells were stimulated with Aging B cell induction stimulation in vitro.As a result the expression of X was confirmed along with induction of age-assosiated B cells. Next, the splenic B cells of gene X-deficient mice were stimulated with Aging B cell induction stimulation in vitro, I found the decrease in age-assosiated B cell induction was observed compared to wild-type mice. Furthermore, analysis of splenic B cells from gene X-deficient aged mice showed that the number of age-assosiated B cells decreased compared to wild-type aged mice. These results sugget that X is involved in the induction of age-assosiated B cell differentiation.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、加齢によりB細胞にて発現するXは新規加齢性B細胞マーカーとなる可能性を示し、Xは加齢性B細胞誘導に関与すること示唆された。本研究成果は、加齢性B細胞の機能や性状の詳細な解明への貢献、そして老化による免疫低下を引き起こす機序をB細胞の視点からの解明に寄与することが示唆され、次世代ワクチンの開発や炎症疾患の新規診断と治療法開発につながる可能性を有しており、超高齢化社会における健康寿命の延長に貢献できることが期待される。