Elucidation of the interaction between the pancreatic cancer-related microbiome and host gene mutations to achieve precision medicine

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15560
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Kyushu University
• Principal Investigator: ABE Toshiya 九州大学, 大学病院, 助教 (20722028)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 膵癌 / Microbiome / 遺伝子変異 / 個別化医療

Outline of Final Research Achievements

Intratumor "F. nucleatum" promotes CXCL1 secretion from cancer cells, contributing to cancer progression in an autocrine and paracrine manners. The CXCL1-CXCR2 axis is activated by "F. nucleatum" to create an immunosuppressive tumor microenvironment, and blockade of this axis suppresses tumor growth. Our results suggest a novel therapeutic approach for intratumor "F. nucleatum"-positive pancreatic cancer patients.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

今回腫瘍内の"F. nucleatum"が腫瘍微小環境を改変し腫瘍成長を促進させることを示した。口腔細菌叢は部分的に膵臓内の微生物叢を表していると考えられ、膵腫瘍内の細菌が悪性腫瘍に影響を与えることを考慮すると、口腔細菌叢の解析が膵癌の新たな治療法の開発に寄与する可能性がある。