2023 Fiscal Year Final Research Report
Elucidating the effect of low-carbohydrate diets containing plant-derived fat on heart failure: focusing on the lipid composition of the diets
Project/Area Number |
22K16096
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53020:Cardiology-related
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Research Institution | The University of Tokyo |
Principal Investigator |
Bujo Satoshi 東京大学, 医学部附属病院, 特任研究員 (20931827)
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Project Period (FY) |
2022-04-01 – 2024-03-31
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Keywords | 心不全 / 低炭水化物食 / 植物性脂質 / ステアリン酸 / PPARα |
Outline of Final Research Achievements |
This study focused on the differences in lipid composition that constitute low-carbohydrate diets (LCDs) aimed at improving risk factors for cardiovascular diseases. Specifically, it aimed to elucidate the effects of LCDs containing plant-derived fat, which have been reported in large clinical trials to reduce cardiovascular deaths in the heart using molecular biological methods. Significantly, our study found that LCDs containing animal-derived fat exacerbated cardiac function in a murine pressure overload heart failure model, while those with plant-derived fat ameliorated it. Transcriptome and fatty acid composition analyses of murine hearts revealed that stearic acid, a key component in LCDs with plant-derived fat, activated the transcription factor PPARα. This activation enhanced fatty acid energy metabolism and regulated inflammation, effectively suppressing heart failure.
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Free Research Field |
心不全
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Academic Significance and Societal Importance of the Research Achievements |
様々な臨床試験から心不全に適した食事療法の探索が続けられているが、分子生物学的な根拠に基づいた心不全予防・治療食の確立が喫緊の課題である。本研究は、これまで臨床試験で報告された高植物性脂質LCDの心疾患抑制効果の一端を、心不全モデルマウスを用いて科学的に解明した。今後の臨床応用への進展に資する成果であり、分子機序をさらに詳細に探索することで、心不全新規治療を目指した研究などへの展開も期待される。
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