The regulatory mechanism via oxidized LDL in obesity-related asthma

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K16177
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Keio University
• Principal Investigator: Mochimaru Takao 慶應義塾大学, 医学部(信濃町), 共同研究員 (60594570)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 肥満喘息 / 酸化LDL / 好酸球

Outline of Final Research Achievements

Obesity is a factor that makes asthma difficult to treat, and causes resistance to inhaled steroids. Obesity frequently coexists with dyslipidemia, which results in high levels of low-density lipoprotein (LDL), but the pathological significance of LDL in allergic diseases, especially asthma, has not been elucidated. In this study, we investigated the direct effect of oxidized LDL on human eosinophils and showed that oxidized LDL promotes the adhesion response of eosinophils and activates and prolongs their survival. We demonstrated that stimulation with IL-33 and TNF-alpha increases the expression of LOX-1, a receptor for oxidized LDL, in human eosinophils.

Free Research Field

asthma

Academic Significance and Societal Importance of the Research Achievements

喘息は慢性気道炎症によるアレルギー疾患であり、肥満は喘息の難治化因子として知られている。本研究では、肥満に高度に合併する脂質異常症に注目し、酸化LDLによる好酸球への影響を検討した。本研究成果により、難治性である肥満喘息への新たな治療戦略への一助となることが期待される。