Establishment of a novel renal pathology evaluation system combining site-specific renal pathology score and functional metabolomic analysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K16238
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Nagoya University
• Principal Investigator: Imaizumi Takahiro 名古屋大学, 医学部附属病院, 特任助教 (40867769)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 腎病理 / 糸球体腎炎 / ネフローゼ症候群

Outline of Final Research Achievements

We evaluated kidney biopsy information by histological site and worked on building a comprehensive kidney pathological evaluation system by integrating clinical information. Specifically, we conducted clinical studies focusing on diseases such as nephrotic syndrome and ANCA-associated vasculitis. In particular, we found that the diagnostic accuracy of the selectivity index of proteinuria, which is useful for diagnosing minimal change nephrotic syndrome, decreases when renal function is impaired. Additionally, we described changes in the disease frequency of ANCA-associated vasculitis. We created a form for collecting clinical information for the kidney biopsy registry and established a system for safely collecting data. Based on the kidney pathology evaluation method we systematized this time, we aim to measure metabolites in various diseases to improve the accuracy of diagnostic prediction and treatment responsiveness prediction.

Free Research Field

腎臓病学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、腎疾患の診断精度の向上、疾患理解の深化、安全なデータ収集が得られた。腎生検情報を部位別に評価し、臨床情報と組み合わせることで診断精度が向上した。特に微小変化型ネフローゼ症候群の診断におけるSelectivity indexの役割を明確にし、腎機能障害時の診断精度低下に注意を促した。疾患頻度の変化を記述し、病理学的変化を分析することで、流行状況やリスク要因の理解が深まった。新たな知見は得られなかったが、今後の予防や治療法の開発に資すると期待される。安全なデータ収集法の開発により、臨床研究の質と安全性が向上し、今後の研究や診療で重要な役割を果たすことが期待される。