2023 Fiscal Year Final Research Report
Molecular Mechanism in NRF2-mediated Dermatitis
| Project/Area Number |
22K16255
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | Nrf2 / アトピー性皮膚炎 / Keap1 / βTrCP |
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| Outline of Final Research Achievements |
In this study, the relationship between Nrf2 and dermatitis using Nrf2-activated mice that developed skin inflammation was analyzed. Comprehensive gene expression analysis using the epidermis of Nrf2-activated mice revealed significant changes in gene expression, including Nrf2 target genes, when compared to mice where the degradation of Nrf2 by Keap1 or βTrCP was blocked individually.
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| Free Research Field |
皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
皮膚が環境から受ける様々なストレスは、アトピー性皮膚炎の発症や悪化に関わるが、その機序は不明な点が多い。これまで、Nrf2は解毒代謝や抗酸化に関わる酵素を制御することはよく調べられてきた。環境ストレスに対するセンサーとして機能するNrf2に注目した本研究の成果は、アトピー性皮膚炎の未解明の機序またはNrf2の新しい機能解明にアプローチできる可能性がある。
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