2023 Fiscal Year Final Research Report
Immunological Mechanisms of Ultraviolet Therapy in Cutaneous T-Cell Lymphoma
| Project/Area Number |
22K16275
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | 菌状息肉症 / CTCL / M2マクロファージ / 紫外線 / FICZ / PAI-1 / MMP-9 |
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| Outline of Final Research Achievements |
The effect of a substance induced from keratinocytes by ultraviolet light (FICZ) on tumor cells and tumor-associated macrophages (TAMs) in cutaneous T-cell lymphoma (CTCL) was examined. The effect of PAI-1 on TAMs was examined, and PAI-1 increased the production of MMP-9. Furthermore, PAI-1 increased MMP-9 production in CTCL cell lines, confirming that suppression of MMP-9 in the mouse CTCL model reduced vascular endothelial cells in the tumor.
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| Free Research Field |
皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究ではPAI-1の抑制がCTCLにおいて重要な役割を果たすことが示され、CTCLに対してPAI-1阻害薬が有効である可能性を示された。将来的にはCTCLの治療薬としてPAI-1阻害薬の適応拡大が進められることが期待される。以上、本研究は研究期間中に新たなCTCLの生物学的メカニズムを解明したことに加え、近い将来の新規CTCL治療薬の開発につながる画期的な研究であったと考える。
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