2023 Fiscal Year Annual Research Report
Elucidating the role of extracellular vesicles microRNA cargo in HIV associated immune dysfunction
| Project/Area Number |
22K16374
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| Research Institution | Kumamoto University |
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Principal Investigator |
BARABONA GODFREY 熊本大学, ヒトレトロウイルス学共同研究センター, 特別研究員 (40906674)
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | miRNA / extracellular vessicle / Inflammation / HIV |
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| Outline of Annual Research Achievements |
We've identified microRNAs within extracellular vesicles that show distinct expression patterns in HIV-infected individuals. We've also established an in vitro system to assess how these extracellular vesicles affect the expression of proinflammatory cytokines in THP-delivered macrophages. Our data indicates a differential impact on cytokine expression in these macrophages when co-cultured with extracellular vesicles derived from HIV-infected individuals compared to those from non-infected individuals. Our next steps include expanding this observation to other cell lines and validating the role of miRNA cargo in cytokine secretion.
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