2022 Fiscal Year Annual Research Report
Restoration of NAD+ via inhibition of CD38 improves aging-induced decline in muscle stem cells functions and muscle regeneration
| Project/Area Number |
22K16408
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| Research Institution | University of Toyama |
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Principal Investigator |
NAWAZ ALLAH 富山大学, 学術研究部医学系, 助教 (80881482)
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| Project Period (FY) |
2022-04-01 – 2023-03-31
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| Keywords | Muscle Regenration / NAD metabolism / Muscle Stem Cell / Immune cells / Aging |
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| Outline of Annual Research Achievements |
Previous reports show macrophages-derived signals are crucial for regeneration process. Both macrophages and satellite cells require nicotinamide adenine dinucleotide (NAD+) for their biological functions. Aging-related decline in NAD+ is reported to impair regenerative process and significantly inhibits satellite cells differentiation. Administration of NAD+ precursors restore NAD+ deficiency in aged muscle and also enhances recovery process. CD38 is an ectoenzyme to degrade NAD+ and is reportedly increased in inflammatory macrophages during aging. However, how inhibition of CD38 affects satellite cells functions in aging-induced delay in recovery process, remain elusive. We are currently investigating how deletion of CD38 in aged mice affect regenerative capacity of muscle stem cells. Our initial results reveal that blocking/inhibition of CD38 results in restoration of NAD+ and muscle stem cell functions.
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Research Products
(3 results)
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[Presentation] Role of adipose tissue-resident macrophages in the regulation of adipocyte and fibro-adipogenic progenitors.2022
Author(s)
Nawaz A, Kado T, Bilal M, Okabe K, Watanabe Y, Aslam MR, Nishimura A, Igarashi Y, Kuwano T, Yagi K, Fujisaka S, Nakagawa T, Tobe K.
Organizer
The 95th Annual Meeting of Japan Endocrine Society Annual Meeting
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[Presentation] Role of adipose tissue-resident macrophages in the regulation of adipocyte and fibro-adipogenic progenitors.2022
Author(s)
Nawaz A, Kado T, Bilal M, Okabe K, Watanabe Y, Aslam MR, Nishimura A, Igarashi Y, Kuwano T, Yagi K, Fujisaka S, Nakagawa T, Tobe K.
Organizer
The 65th Annual Meeting of Japan Diabetes Society Annual Meeting
