Preventive effect of re-expansion lung edema by inhaled Nitric Oxide during minimally invasive cardiac surgery

2024 Fiscal Year Final Research Report

• Project/Area Number: 22K16561
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Kyushu University
• Principal Investigator: Ushijima Tomoki 九州大学, 医学研究院, 講師 (70529875)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Keywords: 低侵襲心臓手術 / 片側性肺水腫 / 一酸化窒素ガス / 体外循環 / 片肺換気

Outline of Final Research Achievements

In an animal model using cardiopulmonary bypass and one-lung ventilation, an increase in inflammatory cytokines, neutrophil counts, and apoptotic cell counts was observed in collapsed lungs, along with worsening pulmonary edema and oxygenation impairment. Inhalation of nitric oxide during reperfusion reduced levels of certain inflammatory cytokines, neutrophil counts, and apoptotic cell numbers in collapsed lungs, thereby improving pulmonary edema and oxygenation.

Free Research Field

心臓血管外科分野

Academic Significance and Societal Importance of the Research Achievements

心臓血管外科領域では低侵襲心臓外科手術が増加しており、その際に人工心肺と片肺換気が併用され、時に虚脱肺での片側性肺水腫が起こることが報告されている。本研究成果は、低侵襲心臓手術においての一酸化窒素ガス吸入により片側性肺水腫を予防できる可能性を示唆するものとなった。