The mechanism of Platelet-Rich Fibrin induced accelerated healing of meniscus injury

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K16741
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Mie University
• Principal Investigator: Senga Yoshiyuki 三重大学, 医学部附属病院, 助教 (70828368)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 多血小板フィブリン / PRF / 半月板 / 再生医療 / 成長因子

Outline of Final Research Achievements

Platelet Rich Fibrin (PRF) is a mass of fibrin containing high concentrations of growth factors and is expected to promote healing in various pathological conditions due to its excellent sustained release properties. We aimed to directly evaluate PRF on meniscal defects in animal models and to identify its effects on meniscal cells and synovial stem cells, which play an important role in tendon repair, as well as its signalling pathways. We found that PRF promoted meniscal fine injury healing compared to the Control and FC groups and activated proliferation of meniscal cells via FGF receptor/Akt signalling.

Free Research Field

整形外科/スポーツ医学/膝・足の外科/再生医療

Academic Significance and Societal Importance of the Research Achievements

本研究を通じて、PRFは半月板損傷の治癒促進に有用であること、特にPRFに含まれるFGF受容体/Aktシグナルを介して半月板細胞の増殖を促し、半月板損傷治癒を促進するというメカ分子学的ニズムを明らかにした。本研究によりPRFを直接半月板損傷の治療に応用できる可能性や特に重要な成長因子であるFGFを半月板損傷の治療に応用できる可能性が示唆されており、今後の新規治療法の開発への一助になったものと考える。