2023 Fiscal Year Final Research Report
Analysis of the Effect of Amyloid Protein Deposition on the Mechanism of Lumbar Disc Degeneration
| Project/Area Number |
22K16768
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | アミロイドーシス / 椎間板 |
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| Outline of Final Research Achievements |
Analysis of intervertebral disc tissue collected from patients with amyloidosis revealed the possibility of increased amyloid deposition in comparison with healthy subjects. In addition, amyloidosis patients have a higher incidence of intervertebral disc injury adjacent to fixation compared to healthy subjects, which is a complication of lumbar spine surgery.We believe that postoperative follow-up should be done with caution in patients with amyloidosis.
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| Free Research Field |
腰部脊柱管狭窄症
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| Academic Significance and Societal Importance of the Research Achievements |
腰椎手術において脊椎固定術の合併症に隣接椎間障害があるが、アミロイドーシス患者は健常者と比べて固定隣接椎間障害をきたす頻度が高いことがわかった。アミロイドーシス患者の場合は注意して術後フォローが必要と考える。
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