Development of novel vital pulp therapy with pulpal function control factor MXRA5

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17037
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Hiroshima University
• Principal Investigator: Yoshida Kazuma 広島大学, 医系科学研究科(歯), 助教 (60846856)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 歯髄幹細胞

Outline of Final Research Achievements

Dental pulp mesenchymal stem cells (DPSC) are expected to be applied to various tissue regeneration as a useful stem cell source due to their high proliferative ability and productivity. Furthermore, it has been reported that DPSCs have a higher cell proliferation ability than bone marrow-derived mesenchymal stem cells (BMMSCs). However, the mechanism by which DPSCs maintain high proliferative capacity remains unclear. In this study, we searched the NCBI GO analysis database to clarify the molecular basis of the high proliferative capacity of DPSCs.

Free Research Field

歯内療法学

Academic Significance and Societal Importance of the Research Achievements

DPSCの高い増殖能を持つ分子基盤を明らかにすることによって，現在では難しいDPSCの臨床応用を行うことに近づけることができる。また，BMMSCとの違いを見出すことによって，BMMSCに対する相違点，細胞の性質などを把握することによって，未分化性が高く維持されているＢＭＭＳＣに対する理解が一歩前進する。