2023 Fiscal Year Final Research Report
Molecular epidemiological study of NLRP3 inflammasome-mediated interaction between periodontal disease and diabetes mellitus
Project/Area Number |
22K17063
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 57030:Conservative dentistry-related
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Research Institution | Nagasaki University |
Principal Investigator |
Higuchi Kanako 長崎大学, 病院(歯学系), 助教 (40892394)
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Project Period (FY) |
2022-04-01 – 2024-03-31
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Keywords | 歯周病 / 糖尿病 / インフラマソーム |
Outline of Final Research Achievements |
Periodontal disease and diabetes mellitus are known to affect each other, and elucidating common exacerbating factors for both diseases is essential for understanding their causal relationship. In this study, we compared the NLRP3 inflammasome priming status of peripheral blood mononuclear cells in patients with Stage II or higher periodontal disease who visited Nagasaki University Hospital. We found that the NLRP3 inflammasome priming status decreased after basic periodontal treatment, suggesting that inflammation in periodontal tissue may affect diabetes via NLRP3 inflammasome priming in the peripheral blood.
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Free Research Field |
歯周病学
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Academic Significance and Societal Importance of the Research Achievements |
歯周病と2型糖尿病との双方向的関連についてはよく知られているが、歯周病がどのようにして2型糖尿病に影響を与えているかについては不明な点が多い。本研究では、歯周組織による炎症が末梢血白血球のNLRP3インフラマソームをプライミングし、プライミングされた末梢血白血球が血流を介して2型糖尿病に影響を与えていることが示唆された。これらは、歯周病と糖尿病の関連についての理解を深めるとともに、これらの疾患の病態の新たな指標となることが期待される。
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