Clinical nutritional risk control strategy for implant treatment based on menaquinone-related bone turnover analysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17143
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Iwamoto Daisei 九州歯科大学, その他部局等, 特別研修員 (60911005)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 顎骨 / 皮質骨幅 / ビタミンK

Outline of Final Research Achievements

This study aimed to clarify the relationship between vitamin K sufficiency and mandible in patients undergoing implant treatment, and further to examine the effects of vitamin K administration in animal experiments, thereby investigating the effectiveness of a nutritional approach using vitamin K for dental implant treatment. First, we examined the relationship between vitamin K sufficiency (blood ucOC concentration) and mandible in patients before implant surgery, revealing a negative correlation between blood ucOC concentration and mandibular cortical bone width. Furthermore, in animal experiments, cortical bone width tended to increase with vitamin K2 administration. These results suggest that vitamin K is related to cortical bone width, and that nutritional intervention with vitamin K may be effective in dental implant treatment.

Free Research Field

補綴系歯学

Academic Significance and Societal Importance of the Research Achievements

超高齢社会を迎えた本邦ではインプラント治療を希望する患者における有病者率は増加傾向にある．中でも骨粗鬆症に罹患している患者では骨量減少及び骨強度の低下が問題視されており，インプラント周囲骨の吸収が骨粗鬆症罹患患者で有意に増加すること，骨粗鬆症患者に骨造成を行っても新生骨の形成が低く成熟骨が有意に少ないことなどが報告されている．本研究により，ビタミンKが下顎骨皮質骨幅と関連し，ビタミンK2の投与で皮質骨幅が厚くなる傾向が明らかとなり，インプラント治療に対する栄養学的アプローチが有効な可能性が示された．