2023 Fiscal Year Final Research Report
Modulation analysis of pain control mechanisms caused by psychosocial stress
| Project/Area Number |
22K17170
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | 中脳水道周囲灰白質 / 社会的敗北ストレス / 慢性疼痛 |
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| Outline of Final Research Achievements |
In this study, we conducted (1) depressive behavior observation experiments (2) changes of head withdrawal reflex threshold (3) electrophysiological analysis of periaqueductal gray matter which is a key point for pain control to investigate the involvement of psychosocial factors in the development of orofacial hyperalgesia using social defeat stress rats. As a result, social defeat stress rats showed remarkable depressive-like behaviors and hyperalgesia such as 1) extension of immobility time, 2) shortening of contact time and 3) decrease of head withdrawal reflex threshold. When compared with the control group, excitatory synaptic transmission in the periaqueductal gray matter showed different changes between excitatory neurons and inhibitory neurons in social defeat stress rats.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
近年、負の感情といった心理的因子が慢性疼痛の成因となる痛覚変調性疼痛という概念が関心を集めている。本研究では、社会的敗北ストレスによってうつ様行動が惹起されるとともに、口腔顔面領域に機械刺激に対する痛覚過敏が惹起されることを示した。さらに、疼痛制御の要衝である中脳水道周囲灰白質内の神経細胞における興奮性シナプス伝達に変化が生じることを示した。本研究は、明らかな神経障害等がない心理的因子の関与のみによっても、口腔顔面領域に疼痛を惹起し疼痛下行抑制経路におけるシナプス伝達に影響を与える事を示唆するもので、今後の難治性慢性疼痛の治療開発における新しい視点となり得る成果といえる。
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