Elucidation of the epigenetics regulation mechanism during osteoclast differentiation and orthodontic tooth movement by TNF-a

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17223
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Noguchi Takahiro 東北大学, 大学病院, 助教 (20907430)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 破骨細胞 / 矯正学的歯の移動

Outline of Final Research Achievements

In this study, we analyzed the role and molecular mechanism of SET7/9 in TNF-α-induced osteoclast differentiation. The results revealed that NF-κB and SET7/9 is involved in RANK expression on osteoclast precursor, which is upregulated by TNF-α. The results also suggest that NF-κB and SET7/9 are involved in osteoclastogenesis through the synergistic effects of TNF-α and RANKL. Furthermore, it was suggested that SET7/9 interacts with p65, a subunit of NF-κB, and that the complex may be translocated into the nucleus by TNF-α.

Free Research Field

矯正歯科

Academic Significance and Societal Importance of the Research Achievements

国内外の破骨細胞形成のエピジェネティクス制御に関する研究は未だ少なく、特にTNF-αが関与する破骨細胞形成に対するヒストン修飾酵素の影響についての報告は皆無である。本研究において、ヒストン修飾酵素SET7/9は破骨細胞前駆細胞に発現し、NF-κBと相互作用し、TNF-αで亢進するRANK発現に影響していることが推測された。病的骨疾患に対するヒストン修飾酵素阻害薬としてSET7/9が重要なターゲットとなる可能性がある。