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2023 Fiscal Year Final Research Report

Large-scale survey of cariogenic bacteria with collagen-binding proteins and their association with systemic disease

Research Project

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Project/Area Number 22K17227
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionOsaka University

Principal Investigator

Matayoshi Saaya  大阪大学, 大学院歯学研究科, 特任講師(常勤) (70910214)

Project Period (FY) 2022-04-01 – 2024-03-31
Keywordsミュータンスレンサ球菌 / 全身疾患 / う蝕
Outline of Final Research Achievements

In the present child subjects, the detection rate of Streptococcus mutans was approximately half that noted in previous reports, suggesting a potential association with the recent decrease in caries prevalence. Furthermore, the highest rate of isolation of S. mutans with collagen binding proteins (CBPs) was observed in the youngest age group 0-6 years old, which highlights the importance of prevention of colonization by such bacteria during infancy. Additionally, caries prevalence was higher in the CBP-positive group as compared to the CBP-negative and non-detection groups, suggesting that the presence of CBPs is a pathogenic factor for caries development.

Free Research Field

小児歯科学

Academic Significance and Societal Importance of the Research Achievements

これまでに、CBP 陽性菌は感染性心内膜炎の発症および病態の悪化に関与することを示してきた。また、感染性心内膜炎の合併症である脳血管疾患をはじめ、非アルコール性脂肪肝炎、IgA 腎症および潰瘍性大腸炎の患者の口腔内からも CBP をコードする遺伝子が高頻度で検出されることが報告されている。しかし、我が国のCBP 陽性菌の分布については未だ不明である。本研究結果から、最も低い年齢群である 0-6歳群において CBP 陽性菌の分離を認める割合が最大であったことから、乳幼児期におけるCBP 陽性菌の定着予防が重要であることが示唆された。

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Published: 2025-01-30  

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