2023 Fiscal Year Final Research Report

Elucidation of lyonization in enamel formation

Research Project

Project/Area Number	22K17249
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 57070:Developmental dentistry-related
Research Institution	Niigata University
Principal Investigator	Kudo Takehisa 新潟大学, 医歯学総合病院, 医員 (70909770)
Project Period (FY)	2022-04-01 – 2024-03-31
Keywords	ライオニゼーション / エナメル形成
Outline of Final Research Achievements	In females, one of X chromosomes is inactivated (X inactivation). X inactivation during organogenesis remains unclear. The present study indicates the possibility that X inactivation occurs randomly, and the subsequent distribution of cells depends on pattern of cell proliferation in each organ.
Free Research Field	口腔解剖学
Academic Significance and Societal Importance of the Research Achievements	器官形成には、X染色体上の遺伝子も多く関わる。そのために、女性におけるX染色体の不活性化が器官形成にどのようにかかわるかを知ることは、先天異常の原因解明に必須となる。本研究結果の成果は、生前診断と生前治療へのアプローチ研究に貢献できる。