2023 Fiscal Year Annual Research Report
Treatment of Periodontitis using stem cell like epithelial cell rests of Malassez
| Project/Area Number |
22K17259
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | malassez / amelogenin / minelarization |
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| Outline of Annual Research Achievements |
In this study, we planned to isolate ERM from mice, but since it was difficult to isolate, we used amelogenin (Emdogain) extracted from pig tooth germ.
In my previous research, I reported that Amelogenin derived from porcine ERM plays a role in inhibiting the calcification of root and alveolar bone. However, it was also shown that amelogenin promotes the calcification of hydroxyapatite in enamel. This implies that the role of Amelogenin may differ based on where and when it is expressed in vivo.
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