Identification of the mechanisms from social determinants of health to cardiovascular events mediated through diabetes.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17392
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kyoto University
• Principal Investigator: Inoue Kosuke 京都大学, 白眉センター, 特定准教授 (80903830)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 糖尿病 / 生活習慣病 / 心血管イベント / 社会決定要因 / 因果推論 / 機械学習

Outline of Final Research Achievements

In the context of identifying social determinants, we utilized nationwide cohort data to demonstrate that among the working-age population of 30-49 years in Japan, there is a link between low income and an increased risk of cardiovascular events (diabetes, hypertension, dyslipidemia, obesity). We also showed that health disparities based on income have widened over the past four years. Additionally, using data from the National Health and Nutrition Examination Survey (NHANES) in the USA, we found that lower educational attainment is associated with a higher risk of death due to diabetes. Further, by applying causal mediation analysis to the same data, we showed that approximately 20% of the effect of a parent's education level on their child's obesity is mediated by income.

Free Research Field

臨床疫学

Academic Significance and Societal Importance of the Research Achievements

本研究結果で得られた結果は、糖尿病をはじめとする生活習慣病が心血管イベント発症リスクを高めるメカニズムにおいて、収入や教育環境などの社会背景因子が重要な役割を有していることを示しており、今後の内科診療・医療政策において社会決定要因がより重要視されることが期待される。