Functional dietary lipids and metabolic disorders

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17771
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Miyamoto Junki 東京農工大学, (連合)農学研究科(研究院), 准教授 (20805668)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: Diet / Nutrition / Gut microbiota / Diertay lipids / Obesity

Outline of Final Research Achievements

The aim of this study was to examine the effects of different dietary lipids on the energy homeostasis through changes gut microbial compositions. As a result, we found that intake of specific dietary lipids improved body and tissue weight gain, glucose intolerance, adipose tissue inflammation, and gut microbial compositions in a high-fat diet-induced obesity mouse model to levels comparable to those of healthy mice.

Free Research Field

腸内細菌学

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、食事、腸内細菌、および生体エネルギー代謝を結びつける重要な役割を担っている可能性が示唆された。近年の食の欧米化に伴う肥満者の増加に対して、腸内細菌を標的とした新しい治療法の確立を目指した知見を提供することが期待される。