The role of newly myonuclear accretion on resistance training-induced health effects expression.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17774
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Toyo University (2023); National Institute of Advanced Industrial Science and Technology (2022)
• Principal Investigator: Ato Satoru 東洋大学, 健康スポーツ科学部, 助教 (20825731)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 筋核 / 筋サテライト細胞 / ミトコンドリア / レジスタンス運動 / 筋肥大 / タンパク質合成

Outline of Final Research Achievements

Resistance exercise is not only an exercise training modality that results in skeletal muscle hypertrophy and increased exerted muscle strength, but has also been shown to improve energy metabolism. During exercise-induced muscle hypertrophy, muscle satellite cells, which are skeletal muscle stem cells, are activated and fused to provide new cell nuclei to multinucleated skeletal muscle cells (myofibers). In this study, we used mice in which muscle satellite cells can be removed, and clarified the possibility that new muscle nuclei mediated by muscle satellite cells may be involved in the maintenance of mitochondrial function during muscle hypertrophy induced by compensatory overload (a model of contraction-induced muscle hypertrophy in experimental animals).

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究によって得られた成果は骨格筋エネルギー代謝を制御する新たな細胞内機構として骨格筋細胞の多核性の役割について今後さらに詳細な機構を研究する上での足掛かり的な知見となったと考える．骨格筋は全身のエネルギー代謝においても重要な役割を果たすことから，今後骨格筋の多核性によるミトコンドリア生後機構の解明は全身のエネルギー代謝調節を改善する新たな介入標的へと発展する可能性がある．
さらに、再生医療分野で開発されている幹細胞操作技術により筋核数の操作が可能になれば、運動の適用が困難な低体力者や高齢者において運動に替わる全く新しい全身代謝機能の改善方策の提供に発展できる可能性がある。