2023 Fiscal Year Final Research Report
Establishment of a novel platform of Raman microscope for diagnosis of hydrogel-generated cancer stem cells.
| Project/Area Number |
22K18179
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | Raman spectroscopy / cancer stem cell / machine learning / material science |
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| Outline of Final Research Achievements |
It was observed that a Raman imaging system integrated with a hydrogel substrate and an advanced data preprocessing pipeline can serve as an effective platform for detecting the presence of cancer stem cells. By using an advanced preprocessing Raman data pipeline, it becomes possible to compare the Raman spectra of cancer cells cultured on hydrogels, which are likely to express stemness markers, with those obtained from standard culture conditions. This approach enhances the sensitivity and specificity of cancer stem cell detection and provides insights into the metabolic alterations that underpin their stemness properties. Consequently, this platform holds great potential for improving cancer diagnosis and treatment by enabling the early detection and characterization of cancer stem cells, ultimately contributing to more targeted and effective therapeutic strategies.
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| Free Research Field |
biophotonics
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| Academic Significance and Societal Importance of the Research Achievements |
Cancer stem cells drive cancer resistance, metastasis, and drug resistance, making it urgent to develop platforms for detecting their presence in tumors and studying their properties. My research aims to create such a platform, enhancing early detection and understanding of cancer stem cells.
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