Early diagnosis of pancreatic cancer by endoscopic ultrasound using novel microvascular imaging

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K18221
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Kindai University
• Principal Investigator: Omoto Shunsuke 近畿大学, 医学部, 講師 (60617364)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: EUS

Outline of Final Research Achievements

This study aims to investigate the contribution of a new technology in endoscopic ultrasonography (EUS) called Detective flow imaging (DFI) to the early diagnosis of biliary and pancreatic diseases. In 2023, the usefulness of DFI for malignant biliary stenosis was presented at domestic and international conferences, demonstrating the feasibility of blood flow diagnosis in biliary tumors and the possibility of differentiating between benign and malignant lesions.

Furthermore, it was revealed that DFI is useful in distinguishing between Intraductal neoplasm of the bile duct (IPNB) and invasive cholangiocarcinoma. A case report on the usefulness of DFI in biliary tumors was also prepared. Additionally, valuable data has been accumulated regarding the evaluation of pancreatic tumors, gallbladder tumors, and IPMN tumor nodules, and an English-language paper is planned for submission.

Free Research Field

胆膵

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、超音波内視鏡検査における新技術Detective flow imagingが、胆膵疾患の早期診断に有用であることを示した点にある。DFIによって、胆道腫瘍の血流診断が可能となり、良悪性の鑑別や、Intraductal neoplasm of the bile duct(IPNB)と浸潤性胆管癌の鑑別が可能になった。

社会的意義としては、DFIを用いることで、胆膵疾患のより早期の発見と治療介入が可能となり、患者の予後改善と医療費削減に貢献できる可能性がある。また、膵腫瘍、胆嚢腫瘍、IPMN腫瘍結節の評価にもDFIが有用であることが示唆されており、今後の臨床応用が期待される。