2023 Fiscal Year Final Research Report
Photoacoustic hyperspectral imaging using mid-infrared light detecting ultrasound
| Project/Area Number |
22K18785
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 21:Electrical and electronic engineering and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
Matsuura Yuji 東北大学, 医工学研究科, 教授 (10241530)
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| Co-Investigator(Kenkyū-buntansha) |
木野 彩子 東北大学, 医工学研究科, 学術研究員 (30536082)
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | 光音響分光法 / 中赤外光 / スペクトラルイメージング |
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| Outline of Final Research Achievements |
The purpose of this study was to perform imaging of biomolecular components by detecting ultrasonic waves generated inside biological tissues when pulse-modulated mid-infrared light is irradiated to the tissues. First, using a piece of beef as a sample, we succeeded in acquiring images according to the muscle and fat components. Next, we focused on 2HG, which is considered to be a marker of brain tumors, and performed imaging of porcine brain with 2HG added.
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| Free Research Field |
医用光工学
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| Academic Significance and Societal Importance of the Research Achievements |
近赤外レーザを用いて行われている光音響イメージングを中赤外レーザを用いて行うには高価かつ大型のレーザを必要とするが，本研究の手法ではQCLを用いることにより小型かつ安価なシステムを構成でき，非接触での腫瘍イメージングなどへの応用が期待できる．また中赤外レーザパルス光照射により生成される超音波発生メカニズム自体が未解明な点が多いうえ，それを生体組織分光に応用しようとする報告はこれまでなく，学術的な意義も高い．
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