2023 Fiscal Year Final Research Report
Neuron-level brain-artificial brain interface
| Project/Area Number |
22K19261
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | 光遺伝学 / ホログラフィ / 高速イメージング / 3Dイメージング |
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| Outline of Final Research Achievements |
We have developed basic technologies for arbitrary light manipulation pattern stimulation and neural activity recording in the C. elegans cranial nervous system. Specifically, we detected a group of neurons in the head of C. elegans using our original high-speed light-sheet microscope, constructed a system to selectively manipulate specific groups of neurons using holography technology, and developed a program to calculate the position and neural activity of each neuron in real time based on the results of high-speed 3D imaging. The results of these studies were used to develop a system to selectively manipulate specific groups of neurons using holographic technology. The system is expected to enable optical manipulation and recording of neuronal activity of a single neuron in freely behaving C. elegans. Using the data obtained by the developed technology, it is expected to be possible to construct a more accurate model of the nervous system than before.
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| Free Research Field |
バイオフォトニクス
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、脳神経系のはたらきを理解するという自然科学の一つの究極的な目標に対して、光操作と光観察を組み合わせた新たな方法論の開拓により迫るものであり、高い学術的意義を有する。実際、線虫の比較的単純な脳神経系に対してすら、神経活動の記録および操作技術が未熟であるがゆえに、神経ネットワークの動作原理は不明のままである。本研究において、観察及び操作にかかわる光学技術およびそれらに伴う画像処理などの情報技術を開拓することで、神経系の動作機序解明のための新たなアプローチとなりうることがわかり、神経科学、光学、情報科学の分野をまたいだ学術的価値を創造したといえる。
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