2023 Fiscal Year Final Research Report

Does the use of pathways controlling humoral immunity fluctuate?

Research Project

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Project/Area Number	22K19352
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
Research Institution	National Agriculture and Food Research Organization
Principal Investigator	Nishide Yudai 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 主任研究員 (50558096)
Co-Investigator(Kenkyū-buntansha)	森山実国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (30727251) 春本敏之京都大学, 白眉センター, 特定助教 (60727387)
Project Period (FY)	2022-06-30 – 2024-03-31
Keywords	液性免疫 / Imd経路 / Toll経路 / 抗菌ペプチド
Outline of Final Research Achievements	Humoral immunity in insects has generally been studied in Drosophila. However, differences between strains may have been overlooked because of the genetically homogenised model insects such as Drosophila. We have previously presumed that the mechanisms regulating the activation of humoral immunity may differ between strains using stinkbug, Plautia stali. In this study, we discovered that the use of humoral immunity differs even when strains originated a few females that collected at the same location. In the future, we would like to confirm the results in the brown tree stink bug using RNAseq and other methods, and to see if this is also the case in other insects.
Free Research Field	昆虫免疫
Academic Significance and Societal Importance of the Research Achievements	昆虫においても免疫は体を守る重要な機構である。その機構は、ある種では代表的な系統を使って明らかにした気になっていた、しかし、系統間でも異なる可能性を示すことは、大いに意義があり、学術的な波及効果は大きいだろう。免疫はこれまでにない害虫防除の方法を産みだす可能性のあるものである。本研究で用いたチャバネアオカメムシは害虫であるし、カメムシ目昆虫は多くの害虫を含む。また、昆虫で見つかったToll経路を司る遺伝子"Toll"はヒトのToll like receptor(TLR)と相同遺伝子であることから、脊椎動物の免疫研究に影響を与える可能性もある。