Novel therapeutic strategies for DNA repair-deficient cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K19382
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 47:Pharmaceutical sciences and related fields
• Research Institution: Yokohama City University
• Principal Investigator: Adachi Noritaka 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)
• Project Period (FY): 2022-06-30 – 2024-03-31
• Keywords: DNA修復 / がん / 遺伝子発現

Outline of Final Research Achievements

In this research project, an extensive number of DNA constructs were systematically constructed to develop novel strategies for assessing the state of DNA repair in cultured cells and tumor tissues. Using these constructs, we have succeeded in rapidly detecting the cellular status of homologous recombination and mismatch repair, which act as guardians of the human genome.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

DNA修復機構の異常は悪性腫瘍全体の25％以上にみられる。本研究の成果は、特定の悪性腫瘍におけるDNA修復の状態を正確に判定するための基盤技術となり、適切な化学療法を選択するための正しい判断基準の提供につながると期待できる。