2023 Fiscal Year Final Research Report
MHC dressing via trogocytosis
| Project/Area Number |
22K19391
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 47:Pharmaceutical sciences and related fields
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | トロゴサイトーシス / 樹状細胞 / MHCクラスI / 抗原提示 |
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| Outline of Final Research Achievements |
Trogocytosis is an active process whereby plasma membrane proteins are transferred from one cell to the other cell in a cell-cell contact-dependent manner. Conventional dendritic cells (DCs) reportedly acquire MHC class I (MHCI) via trogocytosis and subsequently prime CD8+ T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, this mechanism is not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). These results suggest that trogocytosis-mediated MHCI dressing is involved in inflammatory diseases associated with cell death and type I IFN production.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、MHC クラスI分子を身に纏った（ドレス化）樹状細胞による新しい細胞性免疫誘導メカニズムが明らかとなった。このMHCクラスI分子のドレス化を自在にコントロールする方法が開発できれば、それを正に調節することによって、がんやウイルス感染に対する防御機能を高めることに繋がり、逆に負に調節すれば、自己免疫疾患の発症抑制に繋がることが期待される。
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