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2023 Fiscal Year Final Research Report

Beyond Steroids: Toward the Development of Novel Therapies for Autoimmune Diseases.

Research Project

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Project/Area Number 22K19428
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research InstitutionShiga University of Medical Science

Principal Investigator

Nishi Eiichiro  滋賀医科大学, 医学部, 教授 (30362528)

Project Period (FY) 2022-06-30 – 2024-03-31
Keywords自己免疫疾患 / ステロイド / ナルディライジン
Outline of Final Research Achievements

Diseases caused by autoimmune mechanisms include many diseases for which effective treatments are scarce and steroids are the only therapeutic agents. We investigated the potential of nardilysin (NRDC)-targeted therapies as an alternative to steroids, as mouse deficient in NRDC (NRDC-KO) conferred disease resistance in several inflammatory models. In this study, we used T- and B-cell-specific deficient mice and showed that NRDC expressed in lymphocytes may play an important role in the pathogenesis of several autoimmune diseases (autoimmune hepatitis and systemic lupus erythematosus).

Free Research Field

病態医化学 薬理学 内科学

Academic Significance and Societal Importance of the Research Achievements

我が国では、原因不明、治療方針が未確定で後遺症を残すおそれが少なくない300以上の疾患を指定難病と認定してます。その中には自己免疫機序を原因とし、ステロイドが唯一の治療薬である疾患が多く含まれていますが、ステロイドの長期内服が必要な患者は、その重篤な副作用に苦しめられています。我々は、ナルディライジン(NRDC)という分子を欠損したマウスを用い研究を行い、この分子を抑制することが新たな自己免疫性疾患治療薬開発につながる可能性を示しました。今後もNRDCを標的とする治療薬がステロイドの代替となる可能性を追求します。

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Published: 2025-01-30  

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