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2023 Fiscal Year Final Research Report

Mechanisms of cancer cell clonal expansion via phenotypic and spatial diversity in the cancer microenvironment.

Research Project

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Project/Area Number 22K19527
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 53:Organ-based internal medicine and related fields
Research InstitutionOsaka University

Principal Investigator

Takehara Tetsuo  大阪大学, 大学院医学系研究科, 教授 (70335355)

Co-Investigator(Kenkyū-buntansha) 小玉 尚宏  大阪大学, 大学院医学系研究科, 助教 (10623275)
Project Period (FY) 2022-06-30 – 2024-03-31
Keywords膵癌 / 癌微小環境 / 多核球系骨髄由来免疫抑制細胞 / 慢性炎症
Outline of Final Research Achievements

Disregulation of inflammation and the resulting triggering of phenotypic diversity of immune cells in the cancer microenvironment may be involved in the progression of pancreatic cancer and resistance to cancer immunotherapy, but this has not been investigated in detail. Therefore, we focused on the phenotypic and spatial diversity of the cancer microenvironment in pancreatic cancer with the aim of elucidating the pathogenesis and progression mechanisms of pancreatic cancer. Analysis of the cancer microenvironment in human and mouse pancreatic cancer revealed that the interaction between inflammation-based cancer cells, polymorphonuclear bone marrow-derived immunosuppressive cells and CD8 T cells is important in the progression of pancreatic cancer.

Free Research Field

膵癌

Academic Significance and Societal Importance of the Research Achievements

本研究により、膵臓内の組織微小環境で生じる慢性炎症が膵癌の発症や進展に与える影響が明らかとなり、その関係を繋ぐ重要な免疫細胞集団が同定されたことで、今後これらの細胞を標的とした治療薬開発に繋がる可能性が期待される。その結果非常に予後不良な膵癌患者の予後改善に寄与する可能性のある研究成果であり、その社会的意義は極めて大きいと考える。また、膵炎と膵癌を繋ぐ新たな分子機序の解明は、炎症と癌という近年注目されている学問領域の発展に寄与する研究成果であり、学術的にも重要な成果であると考えられる。

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Published: 2025-01-30  

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