Elucidation of the mechanism of muscle regeneration and repair starting from the expansion of macrophage diversity

2024 Fiscal Year Final Research Report

• Project/Area Number: 22K19534
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 53:Organ-based internal medicine and related fields
• Research Institution: Institute of Science Tokyo (2024); Tokyo Medical and Dental University (2023); Nippon Medical School (2022)
• Principal Investigator: Oishi Yumiiko 東京科学大学, 大学院医歯学総合研究科, 教授 (80435734)
• Project Period (FY): 2022-06-30 – 2025-03-31
• Keywords: マクロファージ

Outline of Final Research Achievements

This study focused on the pathogenic mechanism of age-related loss of muscle mass and strength (sarcopenia), particularly the intercellular network and regulatory mechanisms involved in impaired regeneration and repair after muscle injury. Single-cell RNA-seq analysis revealed that multiple unknown macrophage subtypes accumulate in the regenerating muscle stroma, that macrophages have diverse spatiotemporal and pathology-specific functions, and that they lead tissue repair through interactions with muscle satellite cells and fibroblasts. In this study, we classified macrophages in terms of function and interaction, and elucidated the role of macrophage diversity in the regulation of tissue inflammation and repair/regeneration at the molecular level.

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Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、加齢関連疾患の病態理解を深めるとともに、再生医療や炎症制御の新たな研究基盤を提供する。また、サルコペニアをはじめとする加齢関連疾患の治療・予防法の開発に貢献する可能性をもつ。特に、高齢化社会における健康寿命の延伸や生活の質（Quality Of Life）の向上に寄与し、医療費削減や社会的負担の軽減にもつながることが期待される。