2024 Fiscal Year Final Research Report
Emergence of taste health medicine based on health checkup big data
| Project/Area Number |
22K19672
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
實松 敬介 九州大学, 歯学研究院, 講師 (70567502)
高井 信吾 九州大学, 歯学研究院, 助教 (30760475)
岩田 周介 朝日大学, 朝日大学, 助教 (60780062)
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| Project Period (FY) |
2022-06-30 – 2025-03-31
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| Keywords | 味覚 / ビッグデータ / 味覚異常 |
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| Outline of Final Research Achievements |
The molecular mechanism of taste disorders is largely unknown. In this study, we conducted a multifaceted analysis of taste test data from a large-scale health checkup big data (approximately 2,000 items) linked to the data to clarify the true cause. The results suggested that the anti-inflammatory drug diclofenac may suppress the responses of sweet and umami taste cells through inhibition of the COX/prostaglandin synthesis enzyme pathway in taste cells, as well as through a direct effect on T1R2/T1R3 sweet taste receptor. The antiarrhythmic drug flecainide was suggested to specifically increase sour taste sensitivity. In addition, a correlation analysis using health checkup data suggested that there may be a correlation between reduced salt taste sensitivity and reduced olfactory discrimination.
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| Free Research Field |
口腔生理
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| Academic Significance and Societal Importance of the Research Achievements |
味覚受容体は、口腔のみならず、消化管、気管、副鼻腔、脳など様々な臓器で発現する。このことから、味覚の異常は、口腔のみならず、全身の臓器でも生じており、栄養・摂食・嚥下障害や生活習慣病、感染症の発症原因となる可能性が示唆されている。本研究により、ヒトにおける味覚障害発症原因の一部が解き明かされた。また、他の疾病データとの相関も明らかとなった。本研究成果を起点として、世界初の「味覚健康医療」、つまり、味覚感受性とその原因マーカーを指標・標的とした新規の全身健康改善法の創発が期待される。
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