2023 Fiscal Year Final Research Report
An epidemiological study of the gut microbiota and its related factors affecting the maintenance of mental and physical health in the COVID-19 pandemic
| Project/Area Number |
22K19691
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Ohira Tetsuya 福島県立医科大学, 医学部, 教授 (50448031)
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| Co-Investigator(Kenkyū-buntansha) |
木山 昌彦 福島県立医科大学, 医学部, 博士研究員 (10450925)
今野 弘規 近畿大学, 医学部, 教授 (90450923)
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | 腸内細菌叢 / 生活習慣 / 心理的ストレス / 災害 / 地域住民 |
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| Outline of Final Research Achievements |
Based on the hypothesis that the intestinal microflora is prophylactically involved in the occurrence of psychological stress in the COVID-19 pandemic, this study examined the intestinal microflora of residents of Akita Prefecture, Osaka Prefecture, and the evacuation area in Fukushima Prefecture in conjunction with health check-ups, and found that residents of Fukushima Prefecture had a higher proportion of lactobacilli than other areas, especially in men, It was thought that it would be useful to compare lactobacilli with respect to regional differences. In addition, an inverse association was found between the proportion of butyrate-producing bacteria and subjective stress, suggesting that butyrate-producing bacteria may increase stress tolerance. Furthermore, a randomized controlled trial to increase positive psychological factors showed no apparent effect on defecation, but a reduction in psychological stress.
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| Free Research Field |
疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、心理的ストレスと腸内細菌叢との関連について、異なる3地域において検討した点に新規性がある。ビフィズス菌の割合に地域差がみられたことは、今後地域における心身の健康の違いに腸内細菌叢の違いがどのように影響するかを検討する上で基礎資料となるものと考えられる。また、酪酸産生菌と自覚的ストレスとの間に負の関連がみられたことは、これまで酪酸を含む短鎖脂肪酸がドーパミンやアドレナリンを介してストレス緩和に影響する報告を支持するものであり、自然災害後の心理的ストレスに対して腸内細菌叢の面からの介入を展開できる可能性が示唆されれた。近年自然災害が多発するわが国の対策に応用可能であり社会的意義が大きい。
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