2023 Fiscal Year Final Research Report
Innovation of osteoporosis screening and treatment by fracture risk assessment including 3D structural strength indices of the proximal femur
| Project/Area Number |
22K19698
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Kindai University |
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Principal Investigator |
Iki Masayuki 近畿大学, 医学部, 教授 (50184388)
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| Co-Investigator(Kenkyū-buntansha) |
玉置 淳子 大阪医科薬科大学, 医学部, 教授 (90326356)
梶田 悦子 中京学院大学, 看護学部, 教授 (50135373)
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | fracture risk assessment / hip fracture / 3D bone strength index / osteoporosis / screening |
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| Outline of Final Research Achievements |
The performance of a 3D bone index derived from 2D bone density images of the proximal femur by dual X-ray absorptiometry in assessing fracture risk was tested.
A total of 1872 subjects aged 40 years or older at baseline of the JPOS cohort study were included, and a total of 3004 subjects were analyzed by repeated measurements of predictors. 3D bone indices at the proximal femur were obtained with 3D-Shaper (3D-Shaper Medical). During the follow-up period, 76 patients developed a hip fracture. The area under the ROC curve of the integral volumetric bone density of the greater trochanter for predicting hip fracture (0.723) was significantly greater than that of the reference femoral neck areal bone density (0.680).
The predictive performance of the 3D bone indices obtained from proximal femur areal bone density images was superior to that of the original areal bone density.
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| Free Research Field |
骨粗鬆症の疫学研究、臨床疫学、公衆衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
骨粗鬆症は骨強度の低下を特徴とする。骨強度を規定するのは骨量、骨の材質、骨構造の３要素で、骨量は骨密度、材質は血中骨代謝指標や加齢架橋物質濃度で評価されるが、構造に簡便な評価法がなかった。最近、Humbertらは大腿骨近位部の二重X線吸収法(DXA)による骨密度２次元画像を３次元に再構築し、それから構造強度指標を算出する手法を開発した。これで骨折リスクを正確に表現できれば、骨強度の３要素を考慮した骨折リスク評価法が確立でき、骨折リスク評価に基づく骨粗鬆症検診や診療が実現できる。
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