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2023 Fiscal Year Final Research Report

What is a crucial factor for material biodegradation in vivo?

Research Project

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Project/Area Number 22K19905
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

Kambe Yusuke  国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 主任研究員 (30747671)

Project Period (FY) 2022-06-30 – 2024-03-31
Keywords生分解性 / シルク / ゲル / in vivo / マクロファージ / MMP / 低分子量 / βシート
Outline of Final Research Achievements

In this study, we clarified a mechanism of in vivo degradation of Bombyx mori silk fibroin hydrogels. Immediately upon implantation, active matrix metalloproteinases reached the implanted silk fibroin hydrogel and began cleaving silk fibroin networks, which might result in the loosening of the networks and then enabled immune cells, such as macrophages, to start the bulk-level hydrogel degradation. We also found that the beta-sheet crystalline in silk fibroin hydrogels is a determinant for in vivo hydrogel degradation.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

本研究は、in vivoでの材料の生分解性の解明に取り組んだものであり、得られた知見は、移植された材料の生分解性を知り、制御する上で有用である。また、材料のin vivoでの生分解性を蛍光観察により、非侵襲的に評価する手法は、超音波診断装置やCTなどのモダリティに比べて安価な手法であるため、従来避けられてきた移植材料でのin vivo評価の普及に貢献し得る。

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Published: 2025-01-30  

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