2023 Fiscal Year Final Research Report
Control and detection of biological reactions on integrated circuits through cell immobilization and in vivo sensing microenvironments
| Project/Area Number |
22K19917
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
新津 葵一 京都大学, 情報学研究科, 教授 (40584785)
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | クリック反応 / 細胞固定 / 生体内微小環境 |
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| Outline of Final Research Achievements |
In this study, we conceptualize cells as machines capable of releasing therapeutic agents and receiving biological responses. We envision these cells to engage in bidirectional information exchange with integrated circuits and sensors. Achieving this requires methods to immobilize living cells on substrates, technologies for precise placement of multiple cell types, and mechanisms within cells to respond to microenvironments within living organisms. Utilizing pairs of click-reactive functional groups, cells were effectively immobilized and positioned on substrates. Furthermore, we engineered genetic switches that respond to microenvironments such as elevated cytokine levels in cancerous or inflamed tissues, in comparison to normal tissues.
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| Free Research Field |
生体材料、医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で確立された細胞の配置固定法は、ガラス、金属などのマテリアルの表面と共有結合で安定に固定でき、また、独立して反応する官能基を組み合わせることで、複数の種類の細胞を自在に配置できる。この手法は、センサーへの固定、3D組織培養などへ展開が可能で研究開発の基礎を支える。微小環境応答遺伝子スイッチは、治療実験あるいは細胞治療への展開により新たな治療法の開発に繋がる。この研究は、学術的にも社会的にも大きな意義を持ち、今後の医療やバイオテクノロジーの発展に大きく貢献することが期待できる。
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