Mathematical model for quantitatively analysis the pathophysiological characteristics of mouse photoreceptor cell

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20514
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Ritsumeikan University
• Principal Investigator: Muangkram Yuttamol 立命館大学, 立命館グローバル・イノベーション研究機構(BKC), 研究員 (90962473)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: ionic current model / ion channels / ion homeostasis / mathematical model / simulation model / electrophysiology

Outline of Final Research Achievements

Our study has revealed the electrophysiological characteristics of several ionic currents in photoreceptor cells, the first neurons of the retina, along with estimations of their energy consumption. The simulation results indicate that energy consumption significantly decreases when photoreceptors are exposed to light. This is due to an increase in the activity of hyperpolarization-activated channels, offering new insights into photoreceptor functions. These findings enhance the understanding of electrophysiological activity in photoreceptors under both physiological and pathophysiological conditions, providing valuable information for further research in this field.

Free Research Field

Neurophysiology sensory function

Academic Significance and Societal Importance of the Research Achievements

私たちの結果は、暗所および明所条件下での視細胞機能の理解を促進する。これにより、他の研究者は視細胞の電気生理学的機能をより深く理解することができ、網膜疾患の予防やこれらの疾患に対する治療戦略の開発に役立つ可能性がある。さらに、この研究から得られた知見は、視覚科学および眼科学の進展に貢献し、最終的には患者の治療成績を向上させることが期待される。