2023 Fiscal Year Final Research Report
Development of drug delivery vehicles for medium-sized molecule drugs using short self-assembling peptides: application to the oral mucosa
| Project/Area Number |
22K20515
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | エラスチンペプチド / コアセルベーション / 自己集合能 / 薬物送達システム / 中分子 / 口腔粘膜 |
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| Outline of Final Research Achievements |
The purpose of this study was to develop a drug delivery system for medium-sized molecular drugs, which are currently attracting attention as next-generation drugs. The elastin-derived short-chain peptide developed by us exhibited high self-assembly ability under physiological conditions. Furthermore, model drugs with a higher molecular weight than conventional drugs could be encapsulated inside the peptide and released sustainably. Additionally, this peptide can pass through oral mucosal epithelial cells, which is expected to bypass drug degradation. Therefore, the potential for enhanced delivery via this route was suggested.
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| Free Research Field |
生物化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、エラスチン由来短鎖型ペプチドが生理的条件下で強い自己集合能を示すとともに、幅広い分子量のモデル薬物をペプチド内部に包含できることが明らかとなった。さらにこのペプチドが口腔粘膜を透過できることが示唆された。口腔粘膜は吸収性に優れており、薬効の即効性が期待されるだけでなく、胃腸管や肝臓での分解を回避できる経路である。また注射のような痛みもなく、嚥下困難な状況でも安全に投与することが期待できる。本研究により、中分子医薬品をはじめ経皮吸収が困難な美容成分などの幅広い化合物を、口腔粘膜を経由して投与するためのDDS担体としてこの短鎖ペプチドの利用が期待される。
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