2023 Fiscal Year Final Research Report
Therapeutic and detective effects of hybrid liposomes containing photosensitizers against cancer
| Project/Area Number |
22K20516
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | ナノメディシン / ナノ粒子 / ハイブリッドリポソーム / 光線力学的療法 / PDT / セラノスティクス |
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| Outline of Final Research Achievements |
In this study, we investigated the theranostic (detective and therapeutic) effects of HL-containing indocyanine green on colorectal, esophageal, and breast cancer. In addition, the application of photodynamic therapy (PDT) with HL/ICG was examined. Fusion and accumulation of HL/ICG into esophageal cancer (TE-4) cells and breast cancer (4T1-Luc) cells were observed using a fluorescence microscope. Remarkable inhibition of the enlargement was obtained in the model mice treated with PDT after intravenous administration of HL/ICG based on tumor weight.
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| Free Research Field |
医用生体工学、腫瘍診断・治療学
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| Academic Significance and Societal Importance of the Research Achievements |
がんの死亡者数は増加傾向にあり、副作用のない治療薬の開発が急務である。本研究は、ハイブリッドリポソームのがん選択的な作用を利用したHL/ICGを用いたがん検出や制がん剤としての有用性を明らかにすることで、新たながん診断・治療薬の開発を目指している。本研究成果は、HL/ICGの乳がんや食道がんに対する増殖抑制効果や担がんモデルマウスの腫瘍検出能を明らかにしており、今後の発展が期待される。
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