2023 Fiscal Year Annual Research Report
Visualising superfine cerebrovasculature in MRI using supramolecular self-assembly
| Project/Area Number |
22K20520
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Soni Raghav 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー (10967863)
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | Nanoparticles / self-assembly / 4-arm PEG / MRI contrast |
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| Outline of Annual Research Achievements |
In this study, we have developed a self-assembled iron oxide nanoparticle-based contrast agent that holds immense potential for high-resolution imaging of the cerebrovasculature. The branched polyethylene glycols, with a molecular weight of approximately 10 kDa, are conjugated with iron oxide nanoparticles and fluorescein. The self-assembled fiber structure, formed by electrostatic interaction, is concentration-dependent. At 25 mg/ml, self-assembly fibers measuring 120 nm in length and 50 nm in width are detected. Most importantly, when administered intravenously in a rat model, our self-assembly contrast revealed a significantly enhanced cerebral microvascular network, a finding that could revolutionize conventional MRI imaging. The research findings, which have been presented at several prestigious domestic conferences, have also been published in a renowned international journal.
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