Development of precise synthesis of supramolecular assemblies consisting of oligosaccharides

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20533
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
• Research Institution: Tottori University
• Principal Investigator: Sasaki Norihiko 鳥取大学, 工学研究科, 助教 (30962328)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 超分子集合体 / 自己集合 / 超分子重合 / 種重合 / 超分子グライコポリマー

Outline of Final Research Achievements

Supramolecular assemblies based on saccharides (supramolecular glycopolymers), have already been reported; however, their synthetic procedure including introduction of intermolecular interaction sites to the monosaccharide is still tedious. In this study, we synthesized glucose and glucosamine monosaccharides equipped with fluoroalkyl moieties as intermolecular interaction sites. Their self-assembly behavior was investigated to reveal the effects of molecular design of monosaccharides. Surprisingly, the positions of the fluoroalkyl group in monosaccharides influenced the shape of the supramolecular glycopolymers. Based on this understanding, we synthesized the long nanofiber through seeded supramolecular polymerization. Moreover, supramolecular glycopolymers on the silicon substrate worked as water-repellent surface.

Free Research Field

超分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究によって、種重合法による糖分子からなる超分子集合体の合成を実証した。生体三大高分子のDNAやペプチドのような確立された自己集合制御法が、糖分子を用いた場合でも開拓されていくために、本研究から得られた知見が足掛かりになると期待される。糖分子を用いた超分子集合体の合成方法が発展していくことで、機能調整可能な生体適合性、生分解性に富んだ材料の研究を推進できる。