Structure modification of quaternary ammonium salts toward enantioselective synthesis

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20545
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
• Research Institution: Kwansei Gakuin University
• Principal Investigator: Sakakibara Yota 関西学院大学, 理学部, 助教 (60963220)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: アンモニウム塩 / ラジカル反応

Outline of Final Research Achievements

Quaternary ammonium salts are important structures found in various useful materials, including surfactants. However, their synthesis relies on the traditional nucleophilic substitution reaction, and many structurally challenging compounds remain difficult to synthesize. To address this challenge, this study aimed to establish a new approach to structural modification of ammonium salts. As a result, a synthetic method for substituted alkenyl ammonium salts, which had not previously been synthesized, was successfully developed.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、アンモニウム塩の構造修飾という新たな合成アプローチを実証したことにある。このアプローチにより、これまでは合成困難で世の中に存在しなかった第4級アンモニウム塩を多数合成することができるようになった。また、アンモニウム塩は身の回りの多くの有用物質に含まれる構造であるため、本研究で実証した概念は医農薬品や材料科学などの分野にも新たな選択肢を与えるものである。