2023 Fiscal Year Final Research Report
Structure-function analysis of human bitter taste receptors
| Project/Area Number |
22K20632
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0701:Biology at molecular to cellular levels, and related fields
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | 難生産性タンパク質 / 苦味受容体 |
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| Outline of Final Research Achievements |
Bitter taste receptor TAS2Rs recognize bitter substances in taste cells and other tissues in the body and are considered to have diverse functions beyond bitter taste perception. In this study, I established expression and purification systems for various TAS2R subtypes and successfully prepared the signaling TAS2R complexes with gustducin. The recombinant TAS2Rs would be beneficial for future structural and functional analysis.
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| Free Research Field |
構造生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を基盤として苦味受容体の機能研究を展開することで、将来的には食品・医薬産業への貢献が期待できる。また、本研究で開発した組換えタンパク質発現技術は他の難生産性膜タンパク質へも適用可能であり、これまで機能・構造研究が停滞していた生理学的に重要なタンパク質の研究が進展する可能性がある。
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