Elucidation of Diet-induced Thermogenesis Pathways Mediated by Intestinal GLP-1 via Hypothalamic Vasopressin Neurons.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20745
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0802:Biomedical structure and function and related fields
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Masuda Yuta 京都府立大学, 生命環境科学研究科, 特任助教 (10965750)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: GLP-1 / 体温調節 / バソプレシン神経 / Fiber Photometry / 化学遺伝学

Outline of Final Research Achievements

Postprandial thermogenesis, or diet-induced thermogenesis, is important for maintaining health, but the exact brain mechanisms were not known. Using a Chemogenetic approach, our research showed that the postprandial hormone GLP-1, which is released from the intestine, triggers diet-induced thermogenesis through vasopressin neurons in the hypothalamus. This study explains a part of how the brain controls heat production after eating.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

食後の体熱産生は、過剰なエネルギーの放出や体温維持などの観点で健康維持に重要な生理応答と考えられている。本研究は、食後に分泌されるGLP-１が体熱産生を誘導することを見出し、この作用を調節する視床下部神経を同定した。食事誘発性熱産生のメカニズムの解明は、食事と代謝によるエネルギー収支の恒常性を生理学的に理解するために重要であり、代謝疾患の新規治療法開発にも役立つ基盤研究となる。