Angiogenic effect of local injection of hydroxyapatite electret to the hind limb ischemia

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20756
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Junji Yamaguchi 東京医科歯科大学, 大学院医歯学総合研究科 疾患生理機能解析学分野, 助教 (80964709)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 下肢虚血 / ハイドロキシアパタイト / 生体材料 / 荷電

Outline of Final Research Achievements

To overcome the challenges in current treatments for limb ischemia, we investigated the effects of locally injecting hydroxyapatite electret (HAE), a charged particle that can be inexpensively mass-produced. HAE administration resulted in a decreased rate of limb auto-amputation, preserved blood flow, and increased running distance. These findings suggest that local injection of HAE may be an effective treatment for limb ischemia.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究により確認されたHAEの局所注射による下肢虚血からの保護効果は、安価な治療を提供するという社会的問題の解決にも寄与する可能性があり、その発展性は大きい。また、下肢虚血だけでなく様々な虚血性疾患で応用可能な可能性があり、今後の基礎的研究に寄与する意義のある成果が得られた。