Investigating the Involvement of Dysbiosis in Idiopathic Recurrent Pregnancy Loss

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20763
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0803:Pathology, infection/immunology, and related fields
• Research Institution: Keio University
• Principal Investigator: Suzuki Koichiro 慶應義塾大学, 薬学部(芝共立), 特任助教 (20963432)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 腸内細菌 / ディスバイオーシス / 抗生物質 / 胎児吸収 / 流産 / 不育症

Outline of Final Research Achievements

In this study, we administered various antibiotics with different spectra to mice and evaluated their effects on fetal resorption, gut microbiota, and the immune system of the uterus and the decidua. While some antibiotics did not affect the incidence of fetal resorption, administration of a specific antibiotic to pregnant female mice resulted in a significant increase in fetal resorption. In the intestines of mice administered with the antibiotic that induced fetal resorption, there was an increased abundance of Citrobacter and Enterococcus. Additionally, changes were observed in certain subsets of immune cells in the uterus and the decidua.

Free Research Field

粘膜免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究により、抗生物質の投与による腸内細菌叢の撹乱が流産の原因になり得ることが明らかになった。さらに、流産の発生と相関を示す細菌を見出すことができた。今後の研究によりこれらの細菌が流産の原因になることが示された場合、その細菌をターゲットとする予防・治療法の開発につながる可能性がある。