Development of a novel radio-labeled probe activated by Cherenkov luminescence

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20845
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Chiba University
• Principal Investigator: Kannaka Kento 千葉大学, 大学院薬学研究院, 助教 (60963577)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 核医学治療 / チェレンコフ光 / 光化学反応

Outline of Final Research Achievements

In radio-therapy of cancer, cancer-specific accumulation and retention of radio-labeled probe are important in terms of therapeutic efficiency and side effects. In this study, we designed the molecules with reference of photo-affinity labeling technology. In consideration of the application of deep biological systems, we used Cherenkov luminescence derived from charged particles as a light source.
As a result, the progresses of photoreaction were observed under ultraviolet light irradiation, but the progression of photoreaction could hardly be confirmed under Cherenkov luminescence irradiation mixed with FDG.

Free Research Field

分子イメージング

Academic Significance and Societal Importance of the Research Achievements

がんに対する放射性標識プローブの分子設計は、高い親和性を示す標的リガンドを利用することが多いが、標的に対して共有結合性を示す分子設計を施すことができれば、長期間の滞留性を示す可能性が非常に高い。本研究では、光に応答し分子変換される放射性標識プローブの設計に対する検討結果を示した。これらの結果は、今後の光応答性薬剤開発の参考になると考えられる。